Welcome to ZINC, a free database of commercially-available compounds for virtual screening. ZINC contains over 4.6 million compounds in ready-to-dock, 3D formats. ZINC is provided by the Shoichet Laboratory in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF). To cite ZINC, please reference Irwin and Shoichet, J. Chem. Inf. Model. 2005;45(1):177-82 PDF, DOI. We thank NIGMS for financial support (GM71896).

NEWS: Feb 4: The ZINC 8 release is coming - but still not ready. Read more
Dec 6: New Errata page for ZINC.
Nov 8: A new version of ZINC is scheduled for release in January 2008.
Jan 29: The 2007 ZINC release (ZINC7) is now the default version. To use the previous versions of ZINC please click here for ZINC 6 (2006). or click here for ZINC 5 (2005).

Caveat Emptor: We do not guarantee the quality of any molecule for any purpose and take no responsibility for errors arising from the use of this database. ZINC is provided in the hope that it will be useful, but you must use it at your own risk.

Please select:

Compounds in ZINC may be ordered directly from vendors. Please visit their web sites and tell them you found it in ZINC! We thank these suppliers for making their catalogs available via collaborative agreements.

Whereas you are free to share the results of a ZINC search or a screen of molecules from ZINC, you may not redistribute major portions of ZINC without the express written permission of John Irwin.

Documentation & FAQ pages describe changes to ZINC after the JCIM paper went to press, and are being updated to reflect the new release. Please direct correspondence to databases at docking.org. Join the growing ZINC fan club and other related mailing lists. If you use ZINC to obtain an interesting results, we'd love to hear from you (send us a reprint!). Similarly, if there is something about ZINC you don't like, feel free to drop us a line at comments at docking.org.

We are grateful to
the following for software
to power ZINC:
OpenEye
Scientific
Software
 

Schrodinger, Inc.
Cactvs
and Peter Ertl 's JME
... we also acknowledge: Apache, RedHat Linux, Condor, Perl and mod_perl, Python, MySQL, Slash, Povray, Jmol.
 

DOCK4.0 users: add a substructure record using this script or this one contributed by Zhenting Gao.
Current database statistics.

Last updated: Sept 22 2006 by John Irwin, jji at cgl.ucsf.edu
 

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