UCSF

ZINC01532525

Substance Information

In ZINC since Heavy atoms Benign functionality
October 6th, 2004 12 Yes

Other Names:

"L-Arginine, 99%"

(2S)-2-amino-5-(carbamimidamido)pentanoate; (2S)-2-amino-5-guanidinopentanoate; L-arginine anion

(2S)-2-amino-5-(carbamimidamido)pentanoic acid; (2S)-2-amino-5-guanidinopentanoic acid; (S)-2-amino-5-guanidinopentanoic acid; Arg; L-(+)-arginine; L-Arg; L-Arginin; R

(S)-2-Amino-5-guanidinopentanoic acid

(S)-2-Amino-5-guanidinopentanoic acid 2-hydroxysuccinic acid (1:1)

(S)-2-Amino-5-guanidinopentanoic acid 2-oxopentanedioic acid (1:1)

(S)-2-Amino-5-guanidinopentanoic acid 2-oxopentanedioic acid (2:1)

(S)-2-Amino-5-guanidinopentanoic acid compound with (S)-2-aminopentanedioic acid (1:1)

(S)-2-Amino-5-guanidinopentanoic acid compound with 2-oxopentanedioic acid (1:1)

(S)-2-Amino-5-guanidinopentanoic acid hydrochloride

(S)-2-Amino-5-guanidinopentanoic acid thiazolidine-2,4-dicarboxylic acid (1:1)

(S)-2-Amino-5-guanidinopentanoicacid2-hydroxysuccinicacid(1:1)

(S)-2-Amino-5-guanidinopentanoicacid2-oxopentanedioicacid(1:1)

(S)-2-Amino-5-guanidinopentanoicacidthiazolidine-2,4-dicarboxylicacid(1:1)

(S)-2-Amino-5-guanidinovaleric acid

(S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate; (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid; 2-amino-5-guanidinovalerate; 2-amino-5-gu

(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid

2-amino-5-carbamimidamidopentanoic acid

2-amino-5-carbamimidamidopentanoic acid hydrochloride

2-Amino-5-guanidinopentanoic acid hydrochloride

2-Amino-5-guanidinopentanoic acid hydrochloride hydrate

2-Amino-5-guanidinovaleric acid

2-Amino-5-guanidinovaleric acid; 7004-12-8; Amino acid(Arg-); Arginine; C02385

2-amino-5-guanidinovaleric acid; 74-79-3; L-arginine; arg; arginine

2-Amino-5-guanidinovalericacidmonohydrochloride

4320-30-3; Arginine glutamate (USAN); D02397; Modumate (TN)

5-Oxo-L-proline, compound with L-arginine (1:1); Adiuvant; Arginina pidolato [Spanish]; Arginine PCA; Arginine pidolate; Arginine pyroglutamate; EINECS 260-081-5; G-278; L-Arginine compd. with 5-oxo-L-proline (1:1); L-Proline, 5-oxo-, compd. with L-argini

7675-83-4; Arginine aspartate; D07574; Sargenor (TN)

Arg

Argamine

Arginine

Arginine (INN

ARGININE HYDROCHLORIDE

ARGININE L-

Argininosuccinic acid

ARGININOSUCCINICACID

Argivene

ATCA; Arginine thiazolidinecarboxylate; Arginine, thiazolidinecarboxylate; EINECS 260-857-3; L-Arginine monothiazolidine-4-carboxylate; L-Arginine, mono-4-thiazolidinecarboxalate; LS-21615; Sulfile

CHEBI:13077; CHEBI:42927; CHEBI:21235; CHEBI:6185

D(-)-ARGININE HYDROCHLORIDE

D-(-)-Arginine hydrochloride

D-Arginine

Detoxargin

DL-(+/-)-Arginine Hydrochloride

DL-2-Amino-5-guanidinopentanoic acid monohydrochloride monohydrate

DL-2-Amino-5-guanidinovaleric acid

DL-Arginine

DL-Arginine hydrochloride monohydrate

DL-Arginine hydrochloride, 98%, anhydrous

DL-Arginine monohydrochloride monohydrate

DL-Arginine monohydrochloride monohydrate, 98+%

DL-Arginine Monohydrochloride [32042-43-6]

DL-ARGININE MONOHYDROCHLORIDE; [32042-43-6]

DL-Arginine, 98%

DL-Arginine, free base

FDA

H-Arg-OH

H-Arg-OH.HCl

H-DL-ARG-OH HCL

H-DL-Arg-OH.HCl

JAN

L(+)-Arginine

L(+)-Arginine hydrochloride

L(+)-Arginine, 98+%

L-(+)-Arginine

L-2-Amino-5-guanidinopentanoic acid

L-2-Amino-5-guanidinopentanoic acid hydrochloride

L-a-Amino-d-guanidinovaleric acid

L-Arg

L-Arg-L-glu

L-argininate

L-Arginine 2-oxopentanedioate

L-ARGININE ACETATE

L-Arginine alpha-ketoglutarate

L-Arginine alpha-Ketoglutarate Dihydrate

L-Arginine alpha-Ketoglutarate(2:1) Dihydrate

L-Arginine HCl

L-Arginine HCl (L-Arg)

L-arginine hydrochloride

L-Arginine Hydrochloride [1119-34-2]

L-ARGININE HYDROCHLORIDE; [1119-34-2]

L-arginine L-aspartate

L-ARGININE L-GLUTAMATE

L-Arginine L-malate

L-Arginine monohydrochloride

L-Arginine monohydrochloride, 98+%

L-Arginine, 98+%

L-Arginine, homopolymer; LS-185750; Poly(L-arginine); Polyarginine

L-Arginine-L-Glutamate

L-Arginine-L-pyroglutamate

Levargin

MFCD00002635

MFCD00035566

MFCD00050897

MFCD00058334

MFCD00063117

MFCD00064549

MFCD00064550

MFCD00076114

MFCD00151031

MFCD00216455

MFCD00673325

MFCD00800362

MFCD06804674

MFCD10566446

MFCD16876378

MFCD17976754

Minophagen A

N/A

N5-(Diaminomethylene)-L-ornithine - L-aspartic acid (1:1)

NA

QA-1229

QA-5686

QA-9703

R-Gene 10

R-Gene 10 (Pharmacia Corp.)

S(+)-2-Amino-5-guanidinopentanoic acid L-glutamate salt

Store at 0-5C

USAN

USAN)

USAN); Arginine Glutamate (BAN

USP

USP)

USP); Arginine Glutamate (BAN

USP); Arginine HCl (FDA

USP); Arginine Hydrochloride (JAN

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.63 0.33 -74.97 8 6 1 131 175.212 6
Hi High (pH 8-9.5) 3.64 10.11 -7.64 0 2 0 20 328.209 1

Vendor Notes

Note Type Comments Provided By
UniProt Database Links 001R_FRG3G; 056R_FRG3G; 058R_FRG3G; 095L_IIV3; 104K_THEAN; 104K_THEPA; 104L_IIV6; 2ABB_RAT; 2B_CMVQ; 312R_IIV6; 366R_IIV6; 457L_IIV6; 4ET_HUMAN; 4ET_MOUSE; 4F2_HUMAN; 4F2_MOUSE; 4F2_RABIT; 4F2_RAT; 7LESS_DROME; 7LESS_DROVI; A1AG1_HUMAN; A32CD_DROME; A4_MO ChEBI
ALOGPS_SOLUBILITY 2.28e+00 g/l DrugBank-nutriceuticals
ALOGPS_SOLUBILITY 2.57e+01 g/l DrugBank-experimental
Mp [°C] 200 - 203 Acros Organics
MP 216 - 218 Enamine Building Blocks
MP 216...218 Enamine Building Blocks
Melting_Point 216? dec. Alfa-Aesar
Melting_Point 216° dec. Alfa-Aesar
Mp [°C] 223 - 224 Acros Organics
M.P 226-230 C Indofine
Melting_Point 226? dec. Alfa-Aesar
Melting_Point 226° dec. Alfa-Aesar
MP 228 °C Indofine
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity 95% Fluorochem
Purity 98% Fluorochem
therap ammonia detoxicant, diagnostic aid MicroSource Spectrum
Melting_Point ca 230? dec. Alfa-Aesar
Melting_Point ca 230° dec. Alfa-Aesar
Patent Database Links EP1182261; EP1506970; EP1541585; EP1550442; EP1552745; EP1559433; EP1568283; EP1582208; EP1591118; EP1602667; EP1609462; EP1616963; EP1627884; EP1632228; EP1632233; EP1640001; EP1671630; EP1676570; EP1714650; EP1726303; EP1728507; EP1731146; EP1757312; EP ChEBI
H phrase H319: Causes serious eye irritation Acros Organics
Warnings IRRITANT Matrix Scientific
Target NOS Selleck Chemicals
Target Others Selleck Chemicals
P phrase P280: Wear eye protection/face protection Acros Organics
P phrase P280: Wear eye protection/face protection; P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Acros Organics
R phrase R36: Irritating to eyes. Acros Organics
Reactome Database Links REACT_111140; REACT_111222; REACT_12443; REACT_13736; REACT_1378; REACT_14802; REACT_14806; REACT_14813; REACT_14845; REACT_14848; REACT_14850; REACT_15291; REACT_15318; REACT_15441; REACT_15489; REACT_15542; REACT_15544; REACT_18362; REACT_19313; REACT_1 ChEBI
S phrase S24/25: Avoid contact with skin and eyes. Acros Organics
S phrase S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Acros Organics
S phrase S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S39: Wear eye/face protection. Acros Organics
Notes USP, pyrogen free Apollo Scientific Bioactives
PUBCHEM_PATENT_ID WO1994021816A1 IBM Patent Data
Hazard XI: Irritant Acros Organics

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
NOS2-7-E Nitric Oxide Synthase, Inducible (cluster #7 Of 9), Eukaryotic Eukaryotes 7000 0.60 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
NOS2_HUMAN P35228 Nitric Oxide Synthase, Inducible, Human 7000 0.60 Binding ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description Species
Agmatine biosynthesis
Amino acid transport across the plasma membrane
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing: Ubiquitination & Proteasome degradation
Arginine metabolism
Class C/3 (Metabotropic glutamate/pheromone receptors)
Creatine metabolism
Cross-presentation of soluble exogenous antigens (endosomes)
Cytosolic tRNA aminoacylation
Endosomal/Vacuolar pathway
eNOS activation
ER-Phagosome pathway
G alpha (q) signalling events
Glutathione synthesis and recycling
Mitochondrial tRNA aminoacylation
Na+/Cl- dependent neurotransmitter transporters
Nitric oxide stimulates guanylate cyclase
Phagosomal maturation (early endosomal stage)
Proton/oligonucleotide cotransporters
Urea cycle
VEGFR2 mediated vascular permeability

Reactome Annotations from Targets (via Uniprot)

Description Species
Nitric oxide stimulates guanylate cyclase
Phagosomal maturation (early endosomal stage)

Analogs ( Draw Identity 99% 90% 80% 70% )