Warning: session_start() [function.session-start]: open(/tmp/session/sess_jvde89me70tm4r8idbr6cr5b96, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/auth/DrupalAuthentication.php on line 251

Warning: session_write_close() [function.session-write-close]: open(/tmp/session/sess_jvde89me70tm4r8idbr6cr5b96, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109

Warning: session_write_close() [function.session-write-close]: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/tmp/session) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109
2A5A_HUMAN - Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human (21 Compounds)

Swissprot:
2A5A_HUMAN
Stitch:
2A5A_HUMAN
UniProt:
Q15172
ChEMBL:
CHEMBL4763
Reactome:
REACT_228196
REACT_228285
REACT_11065
REACT_19405
REACT_11063
REACT_200610
REACT_228314
REACT_682
REACT_23879
REACT_150425
REACT_228159
REACT_228251
REACT_228137
REACT_150471
REACT_228261
REACT_228060
PDB:
PPP2R5A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 21 9 1 1
Binding ≤ 1μM 1 1 1 1
Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

AXIN missense mutants destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Beta-catenin phosphorylation cascade

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

CTLA4 inhibitory signaling

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Degradation of beta-catenin by the destruction complex

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Mitotic Prometaphase

Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Platelet sensitization by LDL

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Resolution of Sister Chromatid Cohesion

Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S33 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S37 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S45 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Separation of Sister Chromatids

Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

T41 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

truncations of AMER1 destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
2ABG_HUMAN Q9Y2T4 CHEMBL2507 Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human 21
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21
PTPA_HUMAN Q15257 CHEMBL2505 Protein Phosphatase 2A Regulatory Subunit B', Human 21
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_MOUSE P63330 CHEMBL2451 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse 1
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 1
PPM1J_MOUSE Q149T7 CHEMBL2776 Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1