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5HT6R_HUMAN - Serotonin 6 (5-HT6) Receptor, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Serotonin 6 (5-HT6) Receptor, Human (1,538 Compounds)

Swissprot:
5HT6R_HUMAN
Stitch:
5HT6R_HUMAN
UniProt:
P50406
ChEMBL:
CHEMBL3371
Reactome:
REACT_19327
REACT_17064
PDB:
HTR6

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,538 114 33 26
Binding ≤ 1μM 1,443 90 24 20
Functional ≤ 10μM 783 181 2 3

Reactome Network (2)

Reactome ID Description Species
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_17064 Serotonin receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 166
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 13
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 13
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 35
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 24
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 14

Serotonin receptors

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 133
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 63
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 74
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 27
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 21
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 129
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 92
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 175
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 14
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 39
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 166
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 14 11 9 10

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
5HT6R-1-E Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic 283 71 26 20
5HT6R-2-E Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic 1,274 53 16 15
Uniprot Swissprot Chembl Description Number Shared
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 175
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 166
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 133
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 129
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 95
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 92
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 90
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 74
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 63
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 62
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 48
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 45
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 39
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 35
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 35
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 33
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 32
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 31
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 28
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 27
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 27
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 26
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 25
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 24
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 24
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 22
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 21
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 21
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 20
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 20
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 20
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 20
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 18
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 15
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 15
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 14
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 14
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 14
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 14
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 14
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 14
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 13
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 13
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 13
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 13
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 13
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 13
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 12
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 12
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 11
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 11
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 10
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 9
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 9
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 9
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 9
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 8
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 8
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 8
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 8
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 8
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 8
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 8
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 7
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 7
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 7
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 7
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 7
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 7
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 7
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 7
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 7
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 6
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 6
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 6
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 6
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 6
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 6
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 5
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 5
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 5
5HT5A_MOUSE P30966 CHEMBL3597 Serotonin 5a (5-HT5a) Receptor, Mouse 5
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 5
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 5
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 5
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 4
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 4
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 4
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 4
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 4
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 3
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 3
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 3
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 3
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 3
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 3
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 3
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 3
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 3
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 2
ADA1B_MESAU P18841 CHEMBL3122 Alpha-1b Adrenergic Receptor, Mesau 2
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 2
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 2
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 2
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 2
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 2
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 2
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 2
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 2
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 2
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 2
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 2
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 2
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 2
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 2
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 2
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 2
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 2
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 1
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 1
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 1
5HT6R_MOUSE Q9R1C8 CHEMBL1075268 5-hydroxytryptamine Receptor 6, Mouse 1
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 1
5HT7R_MOUSE P32304 CHEMBL4764 Serotonin 7 (5-HT7) Receptor, Mouse 1
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 1
ACM4_RAT P08485 CHEMBL317 Muscarinic Acetylcholine Receptor M4, Rat 1
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 1
ADA2B_BOVIN O77700 CHEMBL3523 Alpha-2b Adrenergic Receptor, Bovin 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ANDR_RAT P15207 CHEMBL3072 Androgen Receptor, Rat 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
AP2S1_RAT P62744 CHEMBL1697667 AP-2 Complex Subunit Sigma, Rat 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 1
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 1
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CXCR3_HUMAN P49682 CHEMBL4441 C-X-C Chemokine Receptor Type 3, Human 1
CXCR3_MOUSE O88410 CHEMBL5200 C-X-C Chemokine Receptor Type 3, Mouse 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
DYRK2_HUMAN Q92630 CHEMBL4376 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2, Human 1
DYRK3_HUMAN O43781 CHEMBL4575 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
HRH2_CAVPO P47747 CHEMBL2882 Histamine H2 Receptor, Guinea Pig 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 1
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 1
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 1
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 1
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
UR2R_HUMAN Q9UKP6 CHEMBL3764 Urotensin II Receptor, Human 1
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 1
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1