Warning: session_start() [function.session-start]: open(/tmp/session/sess_v9fqo3qei8bee7bjvt8pqdnpp2, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/auth/DrupalAuthentication.php on line 251

Warning: session_write_close() [function.session-write-close]: open(/tmp/session/sess_v9fqo3qei8bee7bjvt8pqdnpp2, O_RDWR) failed: No such file or directory (2) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109

Warning: session_write_close() [function.session-write-close]: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/tmp/session) in /domains/zinc12/htdocs/lib/zinc/user/ZincAuthentication.php on line 109
ACM5_HUMAN - Muscarinic Acetylcholine Receptor M5, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Muscarinic Acetylcholine Receptor M5, Human (470 Compounds)

Swissprot:
ACM5_HUMAN
Stitch:
ACM5_HUMAN
UniProt:
P08912
ChEMBL:
CHEMBL2035
Reactome:
REACT_18283
REACT_16943
PDB:
CHRM5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 470 45 23 24
Binding ≤ 1μM 277 33 17 21
Functional ≤ 10μM 64 10 4 4

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 21
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 21
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 21
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 461
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 468
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 22
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 14
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 14
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 14
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2

Muscarinic acetylcholine receptors

Uniprot Swissprot Chembl Description Number Shared
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 461
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 459
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 468
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 465
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACM5_MOUSE Q920H4 CHEMBL2324 Muscarinic Acetylcholine Receptor M5, Mouse 4 4 4 4
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 48 3 3 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1,053 70 41 43
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1,202 58 34 37
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1,056 55 33 35
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 536 44 30 27

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
ACM5-1-E Muscarinic Acetylcholine Receptor M5 (cluster #1 Of 4), Eukaryotic 91 7 5 3
ACM5-2-E Muscarinic Acetylcholine Receptor M5 (cluster #2 Of 4), Eukaryotic 151 33 18 20
ACM5-3-E Muscarinic Acetylcholine Receptor M5 (cluster #3 Of 4), Eukaryotic 271 10 6 8
ACM5-4-E Muscarinic Acetylcholine Receptor M5 (cluster #4 Of 4), Eukaryotic 10 2 1 0
Uniprot Swissprot Chembl Description Number Shared
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 468
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 465
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 460
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 459
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 59
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 53
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 38
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 36
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 22
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 22
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 21
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 21
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 21
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 20
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 15
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 14
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 14
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 14
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 13
Z50512 Z50512 CHEMBL369 Cavia Porcellus 13
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 12
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 12
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 11
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 11
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 10
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 9
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 9
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 9
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 8
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 7
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 7
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 6
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 6
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 6
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 6
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 6
ACM4_RAT P08485 CHEMBL317 Muscarinic Acetylcholine Receptor M4, Rat 6
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 6
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 6
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 6
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 5
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 5
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 5
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 5
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 5
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 5
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 5
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 5
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 5
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 5
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 5
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 5
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 5
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 4
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 4
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 4
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 4
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 4
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 4
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 4
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 4
Q8WMX0_BOVIN Q8WMX0 CHEMBL2672 Muscarinic Acetylcholine Receptor M1, Bovin 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 4
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 4
Z80024 Z80024 CHEMBL614518 A9 (Fibroblast Cells) 4
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 3
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 3
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 3
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 3
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 3
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 3
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 3
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 3
ACM3_MOUSE Q9ERZ3 CHEMBL5105 Muscarinic Acetylcholine Receptor M3, Mouse 3
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 3
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 3
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 3
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 3
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 3
Z104290 Z104290 CHEMBL1907596 Neuronal Acetylcholine Receptor; Alpha4/beta2 3
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 3
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 2
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 2
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACES_MOUSE P21836 CHEMBL3198 Acetylcholinesterase, Mouse 2
ACHA2_RAT P12389 CHEMBL2584 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat 2
ACHA3_RAT P04757 CHEMBL3818 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat 2
ACHA7_HUMAN P36544 CHEMBL2492 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human 2
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 2
ACHB2_RAT P12390 CHEMBL3001 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat 2
ACHB4_RAT P12392 CHEMBL2658 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat 2
ACHD_TORCA P02718 CHEMBL3916 Acetylcholine Receptor Protein Delta Chain, Torca 2
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 2
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 2
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 2
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 2
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 2
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 2
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 2
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
Z102306 Z102306 CHEMBL613606 Aorta 2
Z104281 Z104281 CHEMBL1907587 Neuronal Acetylcholine Receptor; Alpha3/beta2 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104286 Z104286 CHEMBL1907592 Neuronal Acetylcholine Receptor; Alpha2/beta2 2
Z104287 Z104287 CHEMBL1907593 Neuronal Acetylcholine Receptor; Alpha3/beta4 2
Z104289 Z104289 CHEMBL1907595 Neuronal Acetylcholine Receptor; Alpha4/beta4 2
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 1
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 1
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 1
ACES_BOVIN P23795 CHEMBL4768 Acetylcholinesterase, Bovin 1
ACH10_RAT Q9JLB5 CHEMBL3461 Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat 1
ACHA4_RAT P09483 CHEMBL307 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat 1
ACHP_LYMST P58154 CHEMBL6084 Acetylcholine-binding Protein, Lymst 1
ACM4_MOUSE P32211 CHEMBL4572 Muscarinic Acetylcholine Receptor M4, Mouse 1
ACM5_MOUSE Q920H4 CHEMBL2324 Muscarinic Acetylcholine Receptor M5, Mouse 1
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 1
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 1
AMYP_RAT P00689 CHEMBL2699 Pancreatic Alpha-amylase, Rat 1
AP2S1_RAT P62744 CHEMBL1697667 AP-2 Complex Subunit Sigma, Rat 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH3_CAVPO Q9JI35 CHEMBL5076 Histamine H3 Receptor, Guinea Pig 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 1