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ADCY5_HUMAN - Adenylate Cyclase Type V, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Adenylate Cyclase Type V, Human (46 Compounds)

Swissprot:
ADCY5_HUMAN
Stitch:
ADCY5_HUMAN
UniProt:
O95622
ChEMBL:
CHEMBL3189
Reactome:
REACT_15312
REACT_15333
REACT_18339
REACT_19231
REACT_19327
REACT_19333
REACT_1665
REACT_18274
REACT_15530
REACT_1946
REACT_24023
PDB:
ADCY5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 46 3 1 0
Binding ≤ 1μM 37 2 0 0
Functional ≤ 10μM 1 1 0 0
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24

Adenylate cyclase inhibitory pathway

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24

Adrenaline,noradrenaline inhibits insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 3
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 3
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

G alpha (z) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 3
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1

PKA activation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24

PKA activation in glucagon signalling

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2 0 0 0
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 62 29 5 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 75 8 8 7
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 30 7 7 6
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24 1 1 0
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23 0 0 0
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24 1 1 0
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24 1 1 0
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 30 7 7 6
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24 1 1 0
ADCYA_HUMAN Q96PN6 CHEMBL5854 Adenylate Cyclase Type 10, Human 5 4 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADCY5-1-E Adenylate Cyclase Type V (cluster #1 Of 2), Eukaryotic 40 16 3 3
ADCY5-2-E Adenylate Cyclase Type V (cluster #2 Of 2), Eukaryotic 69 15 3 3
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 10
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 6
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 3
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 3
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 3
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 3
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY2_MOUSE Q80TL1 CHEMBL3049 Adenylate Cyclase Type II, Mouse 2
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 2
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 1
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 1
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 1
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 1
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 1
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 1
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GIPR_RAT P43219 CHEMBL5001 Gastric Inhibitory Polypeptide Receptor, Rat 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1