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ADCY9_HUMAN - Adenylate Cyclase Type IX, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Adenylate Cyclase Type IX, Human (24 Compounds)

Swissprot:
ADCY9_HUMAN
Stitch:
ADCY9_HUMAN
UniProt:
O60503
ChEMBL:
CHEMBL2655
Reactome:
REACT_15312
REACT_15333
REACT_19231
REACT_19327
REACT_19333
REACT_1665
REACT_15530
REACT_1946
REACT_24023
PDB:
ADCY9

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 24 1 1 0
Binding ≤ 1μM 23 0 0 0
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

Adenylate cyclase inhibitory pathway

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

G alpha (z) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

PKA activation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

PKA activation in glucagon signalling

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 75 8 8 7
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 30 7 7 6
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24 1 1 0
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23 0 0 0
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 46 3 1 0
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24 1 1 0
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24 1 1 0
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 30 7 7 6
ADCYA_HUMAN Q96PN6 CHEMBL5854 Adenylate Cyclase Type 10, Human 5 4 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADCY9-1-E Adenylate Cyclase Type IX (cluster #1 Of 2), Eukaryotic 1 1 1 0
ADCY9-2-E Adenylate Cyclase Type IX (cluster #2 Of 2), Eukaryotic 23 0 0 0
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 24
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 24
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 24
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 24
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 23
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY2_MOUSE Q80TL1 CHEMBL3049 Adenylate Cyclase Type II, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GIPR_RAT P43219 CHEMBL5001 Gastric Inhibitory Polypeptide Receptor, Rat 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 1