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ADRB1_HUMAN - Beta-1 Adrenergic Receptor, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Beta-1 Adrenergic Receptor, Human (760 Compounds)

Swissprot:
ADRB1_HUMAN
Stitch:
ADRB1_HUMAN
UniProt:
P08588
ChEMBL:
CHEMBL213
Reactome:
REACT_16927
REACT_19327
PDB:
ADRB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 760 58 28 26
Binding ≤ 1μM 416 45 21 21
Functional ≤ 10μM 504 13 10 12

Reactome Network (2)

Reactome ID Description Species
REACT_16927 Adrenoceptors Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 15
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 24
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 23
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 18
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 17
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 16
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 863
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 874

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 4
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 13
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 13
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 863
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 874
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 10
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 9
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 7
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB1_BOVIN Q9TT96 CHEMBL2313 Beta-1 Adrenergic Receptor, Bovin 6 2 2 2
ADRB1_MOUSE P34971 CHEMBL3440 Beta-1 Adrenergic Receptor, Mouse 16 0 0 0
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 279 42 32 24
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 834 83 38 41
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 495 33 9 11

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADRB1-1-E Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic 702 38 29 16
ADRB1-2-E Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic 345 52 25 28
Uniprot Swissprot Chembl Description Number Shared
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 860
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 614
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 30
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 23
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 22
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 22
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 20
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 17
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 17
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 17
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 16
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 15
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 15
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 15
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 14
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 14
ADRB3_CANFA O02662 CHEMBL4400 Beta-3 Adrenergic Receptor, Canine 14
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 13
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 13
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 13
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 13
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 13
ADRB2_BOVIN Q28044 CHEMBL3373 Beta-2 Adrenergic Receptor, Bovin 13
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 13
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 11
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 11
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 10
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 10
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 10
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 10
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 9
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 9
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 9
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 9
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 9
Z50588 Z50588 CHEMBL373 Canis Familiaris 9
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 8
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 8
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 8
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 8
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 8
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 8
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 7
Z50512 Z50512 CHEMBL369 Cavia Porcellus 7
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 6
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 6
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 6
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 6
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 6
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 5
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 5
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 5
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 5
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 5
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 5
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 5
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 5
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 4
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 4
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 4
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 4
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 4
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 4
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 4
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 4
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 4
NMT1_HUMAN P30419 CHEMBL2593 Peptide N-myristoyltransferase 1, Human 4
NMT2_HUMAN O60551 CHEMBL2849 Peptide N-myristoyltransferase 2, Human 4
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 4
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 4
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 4
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 4
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 4
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 4
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 3
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 3
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 3
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 3
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 2
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 2
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 2
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ADRB1_MOUSE P34971 CHEMBL3440 Beta-1 Adrenergic Receptor, Mouse 2
ADRB2_MESAU P04274 CHEMBL5943 Beta-2 Adrenergic Receptor, Mesau 2
ADRB2_MOUSE P18762 CHEMBL3707 Beta-2 Adrenergic Receptor, Mouse 2
ADRB3_MOUSE P25962 CHEMBL4030 Beta-3 Adrenergic Receptor, Mouse 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 2
PKD2_HUMAN Q13563 CHEMBL5465 Polycystin-2, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50587 Z50587 CHEMBL372 Homo Sapiens 2
5HT5A_MOUSE P30966 CHEMBL3597 Serotonin 5a (5-HT5a) Receptor, Mouse 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ADA1A_RABIT O02824 CHEMBL3637 Alpha-1a Adrenergic Receptor, Rabit 1
ADA1D_RABIT O02666 CHEMBL4407 Alpha-1d Adrenergic Receptor, Rabit 1
ADA2B_BOVIN O77700 CHEMBL3523 Alpha-2b Adrenergic Receptor, Bovin 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
ADRB2_CAVPO Q8K4Z4 CHEMBL5414 Beta-2 Adrenergic Receptor, Guinea Pig 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
CASR_HUMAN P41180 CHEMBL1878 Calcium Sensing Receptor, Human 1
CXCR3_HUMAN P49682 CHEMBL4441 C-X-C Chemokine Receptor Type 3, Human 1
CXCR3_MOUSE O88410 CHEMBL5200 C-X-C Chemokine Receptor Type 3, Mouse 1
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1