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UROK_HUMAN - Urokinase-type Plasminogen Activator, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Urokinase-type Plasminogen Activator, Human (832 Compounds)

Swissprot:
UROK_HUMAN
Stitch:
UROK_HUMAN
UniProt:
P00749
ChEMBL:
CHEMBL3286
Reactome:
REACT_641
PDB:
1C5W (DOCK)
1C5X (DOCK)
1C5Y (DOCK)
1C5Z (DOCK)
1EJN (DOCK)
1F5K (DOCK)
1F5L (DOCK)
1F92 (DOCK)
1FV9 (DOCK)
1GI7 (DOCK)
1GI8 (DOCK)
1GI9 (DOCK)
1GJ7 (DOCK)
1GJ8 (DOCK)
1GJ9 (DOCK)
1GJA (DOCK)
1GJB (DOCK)
1GJC (DOCK)
1GJD (DOCK)
1KDU (DOCK)
1LMW (DOCK)
1O3P (DOCK)
1O5A (DOCK)
1O5B (DOCK)
1O5C (DOCK)
1OWD (DOCK)
1OWE (DOCK)
1OWH (DOCK)
1OWI (DOCK)
1OWJ (DOCK)
1OWK (DOCK)
1SC8 (DOCK)
1SQA (DOCK)
1SQO (DOCK)
1SQT (DOCK)
1U6Q (DOCK)
1URK (DOCK)
1VJ9 (DOCK)
1VJA (DOCK)
1W0Z (DOCK)
1W10 (DOCK)
1W11 (DOCK)
1W12 (DOCK)
1W13 (DOCK)
1W14 (DOCK)
2FD6 (DOCK)
2I9A (DOCK)
2I9B (DOCK)
2NWN (DOCK)
2O8T (DOCK)
2O8U (DOCK)
2O8W (DOCK)
2R2W (DOCK)
2VIN (DOCK)
2VIO (DOCK)
2VIP (DOCK)
2VIQ (DOCK)
2VIV (DOCK)
2VIW (DOCK)
2VNT (DOCK)
3BT1 (DOCK)
3BT2 (DOCK)
3IG6 (DOCK)
3KGP (DOCK)
3KHV (DOCK)
3KID (DOCK)
3M61 (DOCK)
3MHW (DOCK)
3MWI (DOCK)
3OX7 (DOCK)
3OY5 (DOCK)
3OY6 (DOCK)
3PB1 (DOCK)
PLAU

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 832 26 3 35
Binding ≤ 1μM 543 3 0 23

Reactome Network (1)

Reactome ID Description Species
REACT_641 Dissolution of Fibrin Clot Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 307
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 130
UPAR_HUMAN Q03405 CHEMBL4883 Urokinase Plasminogen Activator Surface Receptor, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
UROK_MOUSE P06869 CHEMBL1075311 Urokinase-type Plasminogen Activator, Mouse 4 0 0 0
UROK_PIG P04185 CHEMBL1075030 Urokinase-type Plasminogen Activator, Pig 2 0 0 0
UROK_RAT P29598 CHEMBL1075245 Urokinase-type Plasminogen Activator, Rat 4 0 0 0

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
UROK-1-E Urokinase-type Plasminogen Activator (cluster #1 Of 4), Eukaryotic 242 13 2 27
UROK-2-E Urokinase-type Plasminogen Activator (cluster #2 Of 4), Eukaryotic 512 9 0 6
UROK-3-E Urokinase-type Plasminogen Activator (cluster #3 Of 4), Eukaryotic 22 0 0 1
UROK-4-E Urokinase-type Plasminogen Activator (cluster #4 Of 4), Eukaryotic 57 4 1 1
Uniprot Swissprot Chembl Description Number Shared
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 307
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 225
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 221
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 130
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 117
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 96
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 87
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 65
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 62
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 39
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 27
TRYP_PIG P00761 CHEMBL2366 Trypsin, Pig 27
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 26
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 19
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 19
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 17
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 13
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 12
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 7
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 7
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 6
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 6
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 6
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 5
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 5
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 5
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 5
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 5
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 5
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 5
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 5
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 5
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 5
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 5
TRYD_HUMAN Q9BZJ3 CHEMBL2402 Tryptase Delta, Human 5
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 4
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 4
UROK_MOUSE P06869 CHEMBL1075311 Urokinase-type Plasminogen Activator, Mouse 4
UROK_RAT P29598 CHEMBL1075245 Urokinase-type Plasminogen Activator, Rat 4
UPAR_HUMAN Q03405 CHEMBL4883 Urokinase Plasminogen Activator Surface Receptor, Human 3
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 2
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 2
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 2
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 2
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 2
PLMN_MOUSE P20918 CHEMBL1075299 Plasminogen, Mouse 2
THRB_MOUSE P19221 CHEMBL1075308 Prothrombin, Mouse 2
UROK_PIG P04185 CHEMBL1075030 Urokinase-type Plasminogen Activator, Pig 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
ACCN3_HUMAN Q9UHC3 CHEMBL5368 Amiloride-sensitive Cation Channel 3, Human 1
AOC3_RAT O08590 CHEMBL4592 Amine Oxidase, Copper Containing, Rat 1
SCNNA_HUMAN P37088 CHEMBL1791 Amiloride-sensitive Sodium Channel Alpha-subunit, Human 1
T2AG_HUMAN P52657 CHEMBL4283 Transcription Initiation Factor IIA Gamma Chain, Human 1
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 1
TM11D_HUMAN O60235 CHEMBL1795138 Transmembrane Protease Serine 11D, Human 1
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 1